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KMID : 0617220020130010171
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Duksung Bulletin Phamaceutical Sciences
2002 Volume.13 No. 1 p.171 ~ p.176
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Effect of Butanol Fraction of Panax ginseng Head on Gastric Lesion and Ulcer
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Jeong Choon-Sik
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Abstract
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From our previous result that Panax ginseng head extract had inhibition of gastric damages, the extract was fractionated. Among the hexane, chloroform, butanol and water fractions, butanol fraction showed the most potent inhibition of HCI ethanol-induced gastric lesion, aspirin-induced gastric ulcer, acetic acid-induced ulcer and Shay ulcer. Butanol fraction showed significant increase in mucin secretion, and inhibited malondialdehyde (MDA) and H^+/K^+ATPase activity in the stomach. This results indicate that the effectiveness of the fraction on gastric damages might be related to inhibition of acid secreation, increment of mucin secretion and antioxidant property.
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